• NULIBRY dosing is based on the weight of the child, so you may need to reconstitute more than 1 vial¹

  Recommended initial dosage and titration schedule of NULIBRY for patients less than one year of age by gestational age
  Titration Schedule	Preterm Neonates (Gestational Age <37 weeks) mg/kg once daily	Term Neonates (Gestational Age ≥37 weeks) mg/kg once daily
  Initial Dosage	0.4	0.55
  Dosage at Month 1	0.7	0.75
  Dosage at Month 3	0.9	0.9

• NULIBRY needs to be stored in a medical-grade freezer. The vials of NULIBRY need to be kept in the original carton to protect them from light until ready for use
• NULIBRY must be reconstituted before being administered and it can only be reconstituted with Sterile Water for Injection
• Inject NULIBRY within 4 hours of reconstituting it. Discard all unused reconstituted NULIBRY 4 hours after reconstitution
• NULIBRY should never be exposed to any heat source (eg, microwave or hot water)
• Vials of NULIBRY are for 1-time use only. The vials should be thrown away after use, even if there is unused liquid left in the vial

The NULIBRY delivery comes with:

• 28-day supply of 9.5-mg clear glass vials of NULIBRY
• The full Prescribing Information and Instructions for Use for NULIBRY
• A treatment log to keep track of your patient’s treatments. The caregiver should bring this to each appointment

Additional supplies needed to prepare and administer NULIBRY (please see Instructions for Use for NULIBRY for details):

• 1 vial of Sterile Water for Injection for each vial of NULIBRY needed for 1 dose
• 1 sterile 5 mL syringe for each vial of NULIBRY needed for 1 dose to mix (dissolve) NULIBRY with Sterile Water for Injection
• 1 sterile syringe large enough to hold the total amount of NULIBRY needed for one dose
• Sterile needles (18-gauge recommended)
• Alcohol wipes
• 1 sharps disposal container for throwing away used needles and syringes
• Gloves, if you require the caregiver to wear them
• 1 intravenous administration set with non-DEHP tubing and a 0.2 micron filter
• 1 infusion pump used to give the dose of NULIBRY per your instructions
• Other materials, if recommended by you for the caregiver to properly care for the child’s intravenous access line or port before and after giving a dose of NULIBRY

Please refer to Instructions For Use for detailed steps regarding the preparation and administration of NULIBRY.

View full list of preparation and administration steps

Download the full list of preparation and administration steps

Important things caregivers need to know when administering NULIBRY for IV infusion:

• NULIBRY is injected through a special IV access catheter or port
• NULIBRY must be at room temperature to be administered
• Reconstituted NULIBRY should NOT be shaken and should NOT be exposed to heat
• Instruct caregivers to call you right away with any concerns about side effects

How used supplies and equipment are disposed of is very important:

• Make sure caregivers have been properly educated on how to dispose of used needles and syringes
• They should put their used needles and syringes in an FDA-cleared sharps disposal container right away after use
• If they do not have an FDA-cleared sharps disposal container, they may use a household container that is:
  • made of heavy-duty plastic
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out
  • upright and stable during use
  • leak-resistant
  • properly labeled to warn of hazardous waste inside the container

Please have the caregiver refer to their Caregiver Welcome Pack for full details.